Calcium alpha-ketoglutarate (CaAKG) is a calcium salt of alpha-ketoglutaric Acid (AKG), appearing as a white crystalline powder. AKG is an intermediate metabolite of tricarboxylic acid energy metabolism (TCA), which has the effects of preventing osteoporosis, stabilizing immune system, improving weight gain, prolonging life, regulating aging, etc., and has broad application prospects in the fields of medical treatment, medical beauty, cosmetics, food, health care products, etc. However, AKG is too acidic, large gastrointestinal discomfort, and low utilization in the body, so it is often used by synthetic compounds, such as the use of alpha-ketoglutarate calcium.