Indications:

Benzylpenicillin is indicated for the treatment of the following infections in adults, adolescents, children, newborn infants and pre-term infants, caused by penicillin-sensitive pathogens:

- skin and wound infections

- diphtheria (in addition to antitoxin)

- community acquired pneumonia

- empyema

- erysipelas

- bacterial endocarditis

- peritonitis

- meningitis

- brain abscesses

- osteomyelitis

- infections of the genital tract caused by fusobacteria

Benzylpenicillin is also used for the treatment of the following specific infections:

- anthrax

- tetanus

- gas gangrene

- listeriosis

- pasteurellosis

- rat bite fever

- fusospirochaetosis

- actinomycosis

Furthermore, Benzylpenicillin is also used for complications in gonorrhoea and syphilis (e.g. gonorrhoeal endocarditis or arthritis, congenital syphilis), provided that the isolate of Neisseria gonorrhea is documented to have sensitivity to penicillin . However, in uncomplicated cases, preference should be given to depot penicillins. Benzylpenicillin is not indicated for the treatment of syphilis during pregnancy.

Benzylpenicillin is also used in Lyme borreliosis from the second stage of the disease onwards (meningopolyneuritis Garin-Bujadoux-Bannwarth, acrodermatitis chronica atrophicans, Lyme arthritis, Lyme carditis) if oral penicillin therapy is no longer indicated. During pregnancy, high-dose parenteral Benzylpenicillin administration is recommended from the second stage of Lyme disease onwards to prevent diaplacental infections.

Contraindications:

• Hypersensitivity to the active substance

• History of hypersensitivity to penicillin

• History of a severe immediate hypersensitivity reaction (e.g. anaphylaxis) to another beta-lactam agent (e.g. cephalosporin, carbapenem or monobactam)

Storage:

Do not store above 25°